FH genes, beyond LDL-C, predict CAD
نویسندگان
چکیده
منابع مشابه
Diagnostic Yield and Clinical Utility of Sequencing Familial Hypercholesterolemia Genes in Patients With Severe Hypercholesterolemia.
BACKGROUND Approximately 7% of American adults have severe hypercholesterolemia (untreated low-density lipoprotein [LDL] cholesterol ≥190 mg/dl), which may be due to familial hypercholesterolemia (FH). Lifelong LDL cholesterol elevations in FH mutation carriers may confer coronary artery disease (CAD) risk beyond that captured by a single LDL cholesterol measurement. OBJECTIVES This study ass...
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BACKGROUND While the relationship between total cholesterol (TC) and cardiovascular disease (CVD) progressively weakens with aging, several studies have shown that low TC is associated with increased mortality in older individuals. However, the possible additive/synergic contribution of the two most important cholesterol rich fractions (LDL-C and HDL-C) to mortality risk has not been previously...
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Familial hypercholesterolaemia (FH, MIM 143890) is a dominantly inherited metabolic disorder caused by various mutations of the LDL receptor (LDL-R) gene causing delayed clearance of serum low density lipoproteins (LDL). The prevalence of homozygous FH has been estimated to be 1 in a million in European and North American populations. In central and southern Tunisia, the prevalence of homozygou...
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Department of Medicine, Medical University of South Carolina, Charleston, SC and Ralph A. Johnson VA Medical Center, Charleston, SC; The Biostatistics Center, George Washington University, Washington DC, Harvard Medical School and Massachusetts General Hospital, Boston, MA, Department of Microbiology and Immunology Department of Microbiology and Immunology, Medical University of South Carolina,...
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ژورنال
عنوان ژورنال: Nature Reviews Cardiology
سال: 2016
ISSN: 1759-5002,1759-5010
DOI: 10.1038/nrcardio.2016.62